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WelPacker DAC/LC System(Explosion-proof)

Regular price $999,999.00 USD
Sale price $999,999.00 USD Regular price
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WelPacker DAC system is equipped with a high-pressure constant-flow pump. Depending on the compatible chromatographic columns in the system, pump systems with different flow rates ranging from 100mL/min to 3000mL/min can be provided. It is equipped with a preparative-scale UV-Vis detector that allows selection of different detector specifications based on the detection method's flow rate. 

  • High performance with exceptional reproducibility
  • Seamless automation for straightforward scale-up
  • GAMP and FDA 21CFR Part 11 validated with user-friendly software
  • Comprehensive regulatory compliance (FAT/SAT, IQ/OQ)
  • Precise and consistent gradient control
  • Explosion-proof design (IECEx & KCs)

Contact us directly to get a quote.

Pairs well with

WelPacker DAC Advantages:

  • Hydraulic pressure station protects the packing material and reduces percussion for the ground.
  • Simple pipe layout brings bigger operating space and added convenience.
  • Pneumatic and electric power sources optional reduce the noices and extra cost of gas cylinders.
  • Short packing time avoids bad column efficiency.
  • Piston head keeping contact with column bed avoids bed collapse and poor lifetime.
  • No electrical parts apply to anti-explosion area.
  • Unique fluid/sample distribution ensures high column efficiency.

WelcPacker DAC column complies with the relevant regulations below:

  • ICH Good Manufacturing Practice Guidelines (GMP) for APIs
  • Environmental Health Safety (EHS)
  • ISPE's Pharmaceutical Engineering Design Guidelines
  • GAMP Good Automated Manufacturing Practice
  • International Electrotechnical Commission Certification System for Explosion-proof Electrical Products
  • American Society for Testing and Materials Standards (ASTM)
  • Chinese Drug Administration Law
  • ChP Chinese Pharmacopoeia (2020 Edition)

System Design

The system is divided into a DAC column, liquid circuit control and fraction collection system, detection and electrical control system, etc.

Technical parameters

Other Components Introduction

High-pressure sealing ring

The DAC column tube is sealed with a sealing ring on the frit. The sealing ring consists of a spring-energized high-pressure sealing ring and an O-ring coated with polytetrafluoroethylene for enhanced safety and reliability.

Column tube

The column tube processing adopts the most advanced honing technology, which enables the inner wall roughness to reach <0.2μm. This reduces the wear of the sealing ring, improves the lifespan, and reduces column wall effects, thereby enhancing the performance of the chromatographic column.

Distributor

In the design of the distributor for large-diameter preparative chromatography columns, a new distributor has been developed. Due to the constant number of forced distribution nodes per unit area, the diffusion effect of the sample in the distributor remains unchanged. Therefore, the radial distribution of the sample in the column does not increase as the column diameter increases, ensuring that the diffusion effect of the sample on the distributor and its radial distribution remain unchanged even with an increase in column diameter.

Hydraulic station

The gas-driven hydraulic pump used in the hydraulic station is selected from top-tier suppliers such as Haskel and MAXIMATOR. The gas-driven hydraulic pump consists of three parts: the gas-driven section, the hydraulic section, and the directional control valve. The piston of the gas-driven section is connected to the plunger of the hydraulic section and undergoes automatic reciprocating motion controlled by the directional valve. By utilizing a large area piston and a small area plunger, the pressure of the driving gas acting on the piston is transferred to the plunger, thereby increasing the outlet pressure of the liquid.

Pison turnover support

The stand is made of 304L stainless steel material, which facilitates the assembly and disassembly of pistons of different sizes for preparative columns. It is recommended to use the adjustable piston stand for DAC(≥400) configuration.

Preparative online filter

The preparative inline filter consists mainly of a frit, sealing ring, and clamp. When the liquid passes through the inline filter, particles larger than the pore size of the frit are retained, ensuring that the outgoing liquid is free from large particles and preventing them from entering the chromatographic column and detector. This helps prevent clogging of the preparative column caused by large particles, thereby extending the lifespan of the preparative column. Additionally, it also helps reduce wear and tear on the sealing components.


Homogenization system

The homogenization system consists of a homogenization tank and related equipment, which is used to facilitate the packing of chromatography columns and complete the homogenization process of the packing material before packing. During homogenization, the packing material medium for packing the chromatography column is thoroughly mixed with the packing solvent in the homogenization tank by the motor-driven stirring paddle. It is then rapidly transported into the column tube, effectively avoiding the hazards of dust and volatile solvents, and ensuring the health and safety of laboratory personnel.
The homogenization tank provides functions for homogenization stirring, homogenization circulation, and delivery of homogenization liquid. It can be customized in different volumes to meet the filling requirements of various specifications of chromatography columns.

 

Product Description

WelPacker DAC Advantages:

  • Hydraulic pressure station protects the packing material and reduces percussion for the ground.
  • Simple pipe layout brings bigger operating space and added convenience.
  • Pneumatic and electric power sources optional reduce the noices and extra cost of gas cylinders.
  • Short packing time avoids bad column efficiency.
  • Piston head keeping contact with column bed avoids bed collapse and poor lifetime.
  • No electrical parts apply to anti-explosion area.
  • Unique fluid/sample distribution ensures high column efficiency.

WelcPacker DAC column complies with the relevant regulations below:

  • ICH Good Manufacturing Practice Guidelines (GMP) for APIs
  • Environmental Health Safety (EHS)
  • ISPE's Pharmaceutical Engineering Design Guidelines
  • GAMP Good Automated Manufacturing Practice
  • International Electrotechnical Commission Certification System for Explosion-proof Electrical Products
  • American Society for Testing and Materials Standards (ASTM)
  • Chinese Drug Administration Law
  • ChP Chinese Pharmacopoeia (2020 Edition)

System Design

The system is divided into a DAC column, liquid circuit control and fraction collection system, detection and electrical control system, etc.

Technical parameters

Other Components Introduction

High-pressure sealing ring

The DAC column tube is sealed with a sealing ring on the frit. The sealing ring consists of a spring-energized high-pressure sealing ring and an O-ring coated with polytetrafluoroethylene for enhanced safety and reliability.

Column tube

The column tube processing adopts the most advanced honing technology, which enables the inner wall roughness to reach <0.2μm. This reduces the wear of the sealing ring, improves the lifespan, and reduces column wall effects, thereby enhancing the performance of the chromatographic column.

Distributor

In the design of the distributor for large-diameter preparative chromatography columns, a new distributor has been developed. Due to the constant number of forced distribution nodes per unit area, the diffusion effect of the sample in the distributor remains unchanged. Therefore, the radial distribution of the sample in the column does not increase as the column diameter increases, ensuring that the diffusion effect of the sample on the distributor and its radial distribution remain unchanged even with an increase in column diameter.

Hydraulic station

The gas-driven hydraulic pump used in the hydraulic station is selected from top-tier suppliers such as Haskel and MAXIMATOR. The gas-driven hydraulic pump consists of three parts: the gas-driven section, the hydraulic section, and the directional control valve. The piston of the gas-driven section is connected to the plunger of the hydraulic section and undergoes automatic reciprocating motion controlled by the directional valve. By utilizing a large area piston and a small area plunger, the pressure of the driving gas acting on the piston is transferred to the plunger, thereby increasing the outlet pressure of the liquid.

Pison turnover support

The stand is made of 304L stainless steel material, which facilitates the assembly and disassembly of pistons of different sizes for preparative columns. It is recommended to use the adjustable piston stand for DAC(≥400) configuration.

Preparative online filter

The preparative inline filter consists mainly of a frit, sealing ring, and clamp. When the liquid passes through the inline filter, particles larger than the pore size of the frit are retained, ensuring that the outgoing liquid is free from large particles and preventing them from entering the chromatographic column and detector. This helps prevent clogging of the preparative column caused by large particles, thereby extending the lifespan of the preparative column. Additionally, it also helps reduce wear and tear on the sealing components.


Homogenization system

The homogenization system consists of a homogenization tank and related equipment, which is used to facilitate the packing of chromatography columns and complete the homogenization process of the packing material before packing. During homogenization, the packing material medium for packing the chromatography column is thoroughly mixed with the packing solvent in the homogenization tank by the motor-driven stirring paddle. It is then rapidly transported into the column tube, effectively avoiding the hazards of dust and volatile solvents, and ensuring the health and safety of laboratory personnel.
The homogenization tank provides functions for homogenization stirring, homogenization circulation, and delivery of homogenization liquid. It can be customized in different volumes to meet the filling requirements of various specifications of chromatography columns.

 

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