Citric Acid in Ibrutinib on Ultisil LP-C18

Reference Solution

Column Ultisil LP-C18, 3μm, 4.6×150mm (P/N 00208-21041)
Mobile Phase 25mmol/L NaH2PO4, adjust pH to 1.7 with phosphoric acid
Detection /
Temperature 30℃
Flow Rate 1.0ml/min
Injection Volume 20ul